Refractory status epilepticus in children with and without prior epilepsy or status epilepticus

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Status epilepticus and refractory status epilepticus management.

Status epilepticus (SE) describes persistent or recurring seizures without a return to baseline mental status and is a common neurologic emergency. SE can occur in the context of epilepsy or may be symptomatic of a wide range of underlying etiologies. The clinician's aim is to rapidly institute care that simultaneously stabilizes the patient medically, identifies and manages any precipitant con...

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Refractory status epilepticus.

Refractory status epilepticus (RSE) is a common problem in intensive care units and emergency departments. The important risk factor predisposing patients with SE to RSE is delay in receiving treatment. Self-sustaining SE is associated with progressive, time-dependent development of pharmacoresistance. Early termination of convulsive SE by aggressive treatment is the best way to prevent RSE. RS...

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Refractory status epilepticus

Status epilepticus is a life threatening neurological emergency. In persons with status epilepticus, if administration of a benzodiazepine and at least one antiepileptic drug has failed then management protocols for refractory status epilepticus should be put into effect. The article summarises the causes, effects, pathophysiology and treatment protocols for refractory status epilepticus.The co...

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The Efficacy of Propofol and Midazolam in Treatment of Refractory Status Epilepticus in Children

Background: In this study, we compared the efficacy and safety of propofol and midazolam in treatment of children’s refractory status epilepticus. Methods: We recruited 32 patients with refractory status epilepticus. Of those, 16 were treated primarily with midazolam and 16 received propofol. Results: We achieved complete seizure control in 6 (38%) patients treated by midazolam, and in 10 (63%)...

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Mortality following status epilepticus in persons with and without epilepsy

PURPOSE Incidence of status epilepticus (SE) ranges from 6.8 to 41.0 per 100,000 population. Although SE is associated with significant morbidity and mortality, the temporal relationship between SE, epilepsy, and mortality is less clear. The risk of all-cause mortality following SE with and without prior epilepsy was investigated. METHOD This study identified hospitalizations and emergency de...

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ژورنال

عنوان ژورنال: Neurology

سال: 2016

ISSN: 0028-3878,1526-632X

DOI: 10.1212/wnl.0000000000003550